一项发表在《信号传导与靶向治疗》期刊上的研究，以忍冬花中含量丰富的植物微小RNA MIR2911为范例，揭示了制造工艺对草药效力的影响。研究人员发现，传统的 the researchers used MIR2911, a plant microRNA enriched in honeysuckle, as a proof-of-concept example. They found that traditional water decoction preserved MIR2911 and its antiviral activity, whereas ethanol-based processing, widely used in modern manufacturing, removed most of this RNA and sharply reduced the associated bioactivity.

这项研究从制造角度挑战了现有认知，探讨了在实际的原料采集、干燥、提取和灭菌过程中，功能性植物RNA会发生什么变化。研究结果表明，传统的水煎法能够保留MIR2911及其抗病毒活性，而现代生产中普遍使用的乙醇提取法则会去除大部分RNA，并显著降低其生物活性。